Membrane Budding

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چکیده

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Membrane Budding

Membrane budding is a key step in vesicular transport, multivesicular body biogenesis, and enveloped virus release. These events range from those that are primarily protein driven, such as the formation of coated vesicles, to those that are primarily lipid driven, such as microdomain-dependent biogenesis of multivesicular bodies. Other types of budding reside in the middle of this spectrum, inc...

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Budding dynamics of the lipid membrane.

Liposomes are widely used in industrial engineering systems including cosmetics and pharmaceutical and biotechnological applications. A fundamental understanding of the dynamics of lipid bud formation is required to efficiently produce various high-technological liposomes with well-controlled sizes and shapes. In this study, a novel patterning method of controlling the uniformity of the sizes a...

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Virus entry, assembly, budding, and membrane rafts.

As intracellular parasites, viruses rely heavily on the use of numerous cellular machineries for completion of their replication cycle. The recent discovery of the heterogeneous distribution of the various lipids within cell membranes has led to the proposal that sphingolipids and cholesterol tend to segregate in microdomains called membrane rafts. The involvement of membrane rafts in biosynthe...

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ENTH/ANTH proteins and clathrin-mediated membrane budding.

The epsin N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. Structural analyses and ligand-binding studies have shown that a set of proteins previously designated as harboring an ENTH domain in fact contain a highly similar, yet unique module referred to as an AP180 N-terminal homology (...

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Arenavirus budding resulting from viral-protein-associated cell membrane curvature

Viral replication occurs within cells, with release (and onward infection) primarily achieved through two alternative mechanisms: lysis, in which virions emerge as the infected cell dies and bursts open; or budding, in which virions emerge gradually from a still living cell by appropriating a small part of the cell membrane. Virus budding is a poorly understood process that challenges current m...

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ژورنال

عنوان ژورنال: Cell

سال: 2010

ISSN: 0092-8674

DOI: 10.1016/j.cell.2010.11.030